CA eTrust has thrown up a couple of problems - first a false positive identifying Win32/Tnega.AC in the setup.exe for Office 2000 Professional, with signature version 31.6.6361.0.
However, when having a poke at this it turns out that the current version is 31.6.6367 and 6361 is a few days old. A check of our distribution servers show that every single one of them worldwide failed to download version 31.6.6362 from the CA servers and fell over. This happened at around 2245 GMT on 17/2/09.
Log files are showing the following error: Error [0xc0010003] initializing redistribution job.
If you are running CA eTrust ITM, then it's worth checking that your signatures are up-to-date.