[time 22/04/2008 12:54:21: ID 14: machine xxxxx.com: response 22/04/2008 12:54:46] The Win32/Loodok!generic.2 was detected in C:\DOCUME~1\XXXXX\LOCALS~1\TEMP...\SYSTEM.DLL. Machine: XXXXX, User: XXXXX\xxxxx. Status: File was cured; system cure performed.The subdirectory varies, but it is usually %user profiles%\local settings\temp\ns???.tmp where the question marks indicate a random letter/number. You may find that the subdirectory has vanished by the time you investigate.
This appears to be happening with the installer for Firefox (also tested with Netscape Navigator). You can see the problem if you snooze the AV scanner and then fire up the Firefox installer and leave it running.. the SYSTEM.DLL is clearly there.
Apart from eTrust, VirusTotal gives it a clean bill of health.
As usual with false positives, expect a fix to be issued by CA very soon. The problem seems to be with pattern 5723, so updating to a later virus signature should probably cure it.
Added: Pattern 5724 also reports a positive, but the beta version of 5725 does not. You can download beta signatures from CA here.
Added: 5725 is now available for download as normal, this should cure the problem!